Cytochrome P450 in GtoPdb v.2021.2

The cytochrome P450 enzyme superfamily (CYP), E.C. 1.14.-.-, are haem-containing monooxygenases with a vast range of both endogenous and exogenous substrates. These include sterols, fatty acids, eicosanoids, fat-soluble vitamins, hormones, pesticides carcinogens as well drugs. Listed below the human enzymes, their relationship rodent CYP activities is obscure in that species orthologue may not metabolise same Some enzymes located liver particularly important for drug metabolism, hepatic extrahepatic also contribute to patho/physiological processes. Genetic variation isoforms widespread likely underlies proportion individual disposition. has root symbol CYP, followed by number indicate family, capital letter subfamily numeral enzyme. able multiple substrates, others oligo- or mono- specific.